miR-200c Cancer Research Results

miR-200c, miR-200c: Click to Expand ⟱

Source:

Type: tumour-suppressor miRNA

miR-200c studied particularly in the regulation of epithelial-to-mesenchymal transition (EMT) and cancer metastasis.
miR-200c is a member of the miR-200 family, which includes miR-200a, miR-200b, and miR-200c. These miRNAs are known to play a crucial role in maintaining epithelial cell identity and suppressing EMT, a process by which epithelial cells acquire a mesenchymal phenotype and become more migratory and invasive.

miR-200c has been shown to target several genes involved in EMT and cancer progression, including:

     ZEB1 and ZEB2, transcription factors that promote EMT and cancer metastasis.
     TGF-β, a cytokine that promotes EMT and cancer progression.
     Vimentin, a protein that is highly expressed in mesenchymal cells and is associated with cancer metastasis.

The overexpression of miR-200c has been shown to inhibit EMT and cancer metastasis in various types of cancer, including breast, lung, and ovarian cancer. Conversely, the downregulation of miR-200c has been associated with cancer progression and poor prognosis.

Downregulated in: lung, CRC, GC, pancreatic, HCC (associated with poor prognosis).

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

800-

GAR,

Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

NA,

xenograft mouse model where garcinol was found to inhibit NF-κB, miRNAs, vimentin, and nuclear β-catenin

EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1, Let-7↑, 1,

Migration ⓘ

E-cadherin↑, 1, MET↑, 1, miR-200c↑, 1, Vim↓, 1, Zeb1↓, 1, ZEB2↑, 1, p‑β-catenin/ZEB1↓, 1,

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-200c, miR-200c

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells