DR4 Cancer Research Results

DR4, Death Receptor 4: Click to Expand ⟱
Source:
Type: protein
DR4 (Death Receptor 4, also known as TRAIL receptor 1 or TNFRSF10A).
DR4 is one of the main receptors for TRAIL (TNF-related apoptosis-inducing ligand). • Upon TRAIL binding, DR4 can trigger the extrinsic apoptotic pathway, leading to caspase activation and programmed cell death.

Lower receptor levels often correlate with therapy resistance and aggressive tumor phenotypes, while appropriate or higher levels may enhance susceptibility to apoptosis-based therapies.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
7410- CS,    Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
- in-vitro, BC, MDA-MB-231
selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Apoptosis↑, Dose↝, other↑, BloodF↓, VEGF↓, UroPA↓, PPARα↓, DR4↑, Casp3↑, PPARγ↑, antiNeop↑, Risk↓, 6IL↑,
1928- TQ,    Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

6IL↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

MDA↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARα↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 1,   DR4↑, 3,   DR5↑, 1,   FADD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   TumCI↓, 1,   TumCP↓, 2,   UroPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   Risk↓, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DR4, Death Receptor 4
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 iodine
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:806  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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