DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
4401- AgNPs,  Rad,    Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy
- in-vitro, BC, NA
RadioS↑, DNAdam↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
374- AgNPs,    Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
ER Stress↑, DNAdam↑, ROS↑, Apoptosis↑, GSH/GSSG↓, NADPH/NADP+↓, TumCG↓, UPR↑,
360- AgNPs,  Moringa,    Cytotoxic and Genotoxic Evaluation of Biosynthesized Silver Nanoparticles Using Moringa oleifera on MCF-7 and HUVEC Cell Lines
- in-vitro, BC, MCF-7 - in-vitro, BC, HUVECs
DNAdam↑,
376- AgNPs,    Antitumor activity of colloidal silver on MCF-7 human breast cancer cells
- in-vitro, BC, MCF-7
Apoptosis↑, LDH↓, SOD↑, DNAdam↑,
386- AgNPs,  Tam,    Synergistic anticancer effects and reduced genotoxicity of silver nanoparticles and tamoxifen in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
P53↑, BAX↑, Bcl-2↓, Casp3↑, DNAdam↑, TumCCA↑,
388- AgNPs,    Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells
- in-vitro, BC, MCF-7
ROS↑, Casp3↑, BAX↑, P53↑, Casp↑, Cyt‑c↑, MMP↓, DNAdam↑, Bcl-2↓, BAX↑,
1142- Ash,    Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
- Review, BC, MCF-7 - NA, BC, MDA-MB-231 - NA, Nor, HMEC
Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,
4818- ASTX,  MEL,    Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF-7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
5492- EP,    Nano-Pulse Stimulation Therapy in Oncology
- in-vivo, PC, Panc02 - in-vivo, BC, 4T1
CellMemb↑, Ca+2↑, DNAdam↑, eff↝, Imm↑,
2826- FIS,    Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway
- in-vitro, BC, MDA-MB-453
Apoptosis↑, p‑ENO1↓, DNAdam↑, PI3K↑, p‑Akt↑, HER2/EBBR2↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF-7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
501- MF,    Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell Viability
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
Apoptosis↑, *toxicity↓, ChemoSen↑, chemoP↑, selectivity↑, DNAdam↑,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF-7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB/CCNB1↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, eff↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
2112- TQ,    Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells
- in-vitro, BC, MCF-7
Apoptosis↑, DNAdam↑, ROS↑, GSH↓, MMP↓, Casp3↑, Casp7↑, Casp9↑, Bax:Bcl2↑, P53↑, P21↑, cycD1/CCND1↓, GSSG↑, GSH/GSSG↓,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
2284- VitK2,    Menadione-induced DNA damage in a human tumor cell line
- in-vitro, BC, MCF-7
DNAdam↑, ROS↑,

Showing Research Papers: 1 to 29 of 29

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 29

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GSH↓, 1,   GSH/GSSG↓, 2,   GSSG↑, 1,   Iron↑, 1,   NADPH/NADP+↓, 1,   OXPHOS↓, 2,   PrxII↓, 1,   ROS↑, 16,   SOD↑, 1,   SOD1↑, 1,   Trx1↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 3,   MMP↓, 7,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 2,   ECAR↓, 1,   p‑ENO1↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 1,   PDK1↓, 2,   p‑PDK1↓, 1,   PKM2↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 12,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Casp↑, 2,   Casp3↑, 5,   Casp7↑, 1,   Casp9↑, 3,   Chk2↑, 1,   Cyt‑c↑, 3,   DR5↑, 1,   MAPK↓, 1,   MAPK↑, 1,   MOMP↓, 1,   Myc↓, 1,   necrosis↑, 3,   p27↑, 1,   Paraptosis↑, 1,   survivin↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

H3K18↓, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP?, 1,   GRP78/BiP↑, 1,   PERK↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

SESN2↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

DNAdam↑, 29,   GADD45A↑, 1,   P53↑, 3,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,   cl‑PARP↝, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CSCs↓, 2,   EMT↓, 1,   ERK↓, 2,   Gli1↓, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   mTOR⇅, 1,   PI3K↓, 1,   PI3K↑, 1,   PTCH1↓, 1,   PTEN↑, 1,   Smo↓, 1,   STAT3↓, 2,   TOP1↓, 1,   TumCG↓, 3,   Wnt↓, 2,  

Migration ⓘ

Ca+2↑, 3,   E-cadherin↑, 1,   FAK↓, 1,   GLI2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   NEDD9↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TSC1↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 5,   TumMeta↓, 3,   VCAM-1↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 4,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 6,   Dose↓, 2,   Dose↝, 2,   Dose∅, 1,   eff↓, 2,   eff↑, 12,   eff↝, 1,   MRP1↓, 1,   RadioS↑, 4,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

AR↓, 1,   E6↓, 1,   E7↓, 1,   Ferritin↓, 1,   HER2/EBBR2↓, 1,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 158

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   ROS↓, 1,   ROS∅, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life∅, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   toxicity↓, 3,   toxicity∅, 2,  
Total Targets: 11

Scientific Paper Hit Count for: DNAdam, DNA damage
7 Silver-NanoParticles
3 Radiotherapy/Radiation
2 Betulinic acid
2 Ellagic acid
2 salinomycin
1 Moringa oleifera
1 tamoxifen
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Melatonin
1 Baicalein
1 Baicalin
1 doxorubicin
1 Caffeic acid
1 Zinc
1 Chlorophyllin
1 Electrical Pulses
1 Fisetin
1 Garcinol
1 Curcumin
1 Magnetic Fields
1 Piperlongumine
1 Quercetin
1 Shikonin
1 Thymoquinone
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:82  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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