toxicity Cancer Research Results

toxicity, toxicity: Click to Expand ⟱
Source:
Type:
Toxicity
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
5461- AF,    Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, eff↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5899- CAR,  TV,    Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, selectivity↑, BioAv↝, BBB↑, *toxicity↝, *antiOx↑, COX2/PTGS2↓, 5LO↓,
6788- EGCG,    A systematic review and meta-analysis of the effects of green tea extracts and polyphenols in female hormone-dependent cancers for benefit-risk evaluation
- Review, BC, NA - Review, Ovarian, NA
TumVol↓, TumW↓, *toxicity↝,
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
8173- Lap,  Tras,    Efficacy and safety of lapatinib and trastuzumab for HER2-positive breast cancer: a systematic review and meta-analysis of randomised controlled trials
- Review, BC, NA
CR↑, EFS↑, OS↑, toxicity↝,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
1689- Se,    Selenium and breast cancer - An update of clinical and epidemiological data
- Analysis, BC, NA
OS↑, eff↑, Dose∅, *toxicity↝, eff↑,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CR↑, 1,   EFS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 4,   TrxR↓, 1,   mt-TrxR1↓, 1,   mt-TrxR2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   c-Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 3,   necrosis↑, 1,   p‑p38↑, 1,   Paraptosis↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↑, 1,   Diff↑, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   ATPase↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 2,   ChemoSen↑, 1,   Dose↝, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 6,   MRP1/ABCC1↓, 1,   selectivity↑, 4,   selectivity↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

HER2/EBBR2↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↓, 1,   cardioP↑, 1,   hepatoP↑, 1,   OS↑, 3,   toxicity↝, 5,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 59

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↝, 5,  
Total Targets: 2

Scientific Paper Hit Count for: toxicity, toxicity
1 Auranofin
1 Silver-NanoParticles
1 Baicalein
1 Baicalin
1 doxorubicin
1 Carnosic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 EGCG (Epigallocatechin Gallate)
1 Ginkgolic acids
1 Lapatinib
1 Trastuzumab
1 salinomycin
1 Selenium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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