Dose Cancer Research Results

Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer

Scientific Papers found: Click to Expand⟱
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
6594- Anamu,    Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells
- in-vitro, BC, HCC1806/CRL-2335 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumCP↓, TumCMig↓, Bak↑, GADD45A↑, LTA/TNF-β↑, lysoMP↑, P450↓, cl‑PARP↑, Dose↝,
6887- Ang,    Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development
- in-vivo, BC, 4T1 - in-vitro, BC, MCF7
BAX↑, Bcl-2↓, cl‑Casp3↑, Dose↝, TumCG↓,
4819- ASTX,    Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway
- in-vitro, BC, MCF7
antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,
2502- Bical,    Complete Response of Metastatic Androgen Receptor–Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature
- Case Report, BC, NA
Dose↝, Remission↑,
5916- Cats,  Chemo,    Uncaria tomentosa—Adjuvant Treatment for Breast Cancer: Clinical Trial
- Trial, BC, NA
*DNAdam↓, Neut↓, eff↑, Imm↑, Dose↝,
4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, antiNeop∅, *cardioP↑, Dose↝, selectivity↑, TumCG∅, TumCG∅, Apoptosis∅,
1977- CUR,    Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
TrxR↓, Dose↝, eff↑,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
6758- DHA,  Chemo,    Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial
- Trial, BC, NA
ChemoSen↑, selectivity↑, ROS↑, *toxicity↓, Dose↝,
5386- docx,  AsP,    Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy
- vitro+vivo, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Pca, PC3
Dose↝, ROS↑, eff↑, eff↑,
6617- Ech,    Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
Dose↝, selectivity↑, TumCCA↑, Apoptosis↑, toxicity↓, ChemoSen↑, other↝, *antiOx↑,
6837- EVO,    Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
- in-vitro, BC, MCF7
TOP1↓, Dose↝,
6849- FBZ,    Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients
- Case Report, BC, NA - Case Report, Pca, NA - Case Report, Melanoma, NA
Remission↑, toxicity↓, Dose↝, Dose↝, Dose↝,
6920- FIS,    A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study rationale and trial design
- Trial, BC, NA
Dose↝, cellSen?,
6987- Form,    Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR-542-5p
- vitro+vivo, GC, SGC-7901 - in-vitro, BC, MGC803
antiNeop↑, tumCV↓, TumCMig↓, TumCI↓, Dose↝, miR-542↓, TumCG↓,
6964- Form,    Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo
- vitro+vivo, BC, MCF7
IGF-1↓, IGFR↓, PI3K↓, Akt↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, TumCG↓, Dose↝,
6972- Form,  PacT,    Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy
- in-vivo, BC, MDA-MB-231
AntiCan↑, miR-199↓, ChemoSen↑, TumVol↓, Dose↝, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↓, eff↓,
7032- GA,  Cisplatin,    Gallic acid: a polyphenolic compound potentiates the therapeutic efficacy of cisplatin in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
ChemoSen↑, tumCV↓, Apoptosis↑, selectivity↑, *ROS↓, eff↑, *chemoP↑, Dose↝,
7130- Ge-132,    Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer
- Trial, BC, NA
IL6↓, TumMeta↓, Dose↝, MCP1/CCL2↓,
7145- GI,  Chemo,    Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study
- Trial, BC, NA
Dose↝, toxicity∅, Nausea∅, Vomit∅,
7155- GI,  BSB,    Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer
- Trial, BC, NA
Dose↝, Dose↝, Vomit↓, Nausea↓, *toxicity↓,
7343- Hne,    Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer
- in-vitro, Melanoma, A431 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HaCaT - in-vitro, Nor, JB6
*Dose↝, *antiOx↑, selectivity↑, Bcl-2↓, BAD↑, BAX↑,
7466- HNK,  PDT,  MET,    Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin
- in-vitro, BC, NA
TumCD↓, Dose↝, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, TumCP↓,
7621- HPT,  Rad,    Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone in patients with painful bony metastases: A phase III clinical trial study
- Trial, Pca, NA - Trial, BC, NA
Pain↓, Dose↝, CR↑,
7541- HT,    Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer
- Trial, BC, NA
Dose↝, MMP9↓, TIMP1↓,
7602- I3C,    Dose-ranging study of indole-3-carbinol for breast cancer prevention
- Trial, BC, NA
toxicity↓, Dose↝, 2/16-OHE1↑, chemoPv↑,
7711- IBC,    Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo
- vitro+vivo, BC, NA
SIRT2↓, Dose↝, Snail↓, MMPs↓, STAT3↓, cMyc↓, ROS↑,
7637- Ins,    Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes
- vitro+vivo, BC, 4T1
TumVol↓, Dose↝, *toxicity↓, AMPK↓, Ki-67↓,
7643- Ins,  IP6,    Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical stud
- Trial, BC, NA
RBC↑, QoL↑, eff↑, Imm↑, ChemoSen↑, chemoP↑, Dose↝,
7673- iod,  Chemo,    Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study
- Trial, BC, NA
Dose↝, *chemoP↑,
7672- iod,    Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study
- Trial, BC, NA
Dose↝, OS↑, TumCI↓, Apoptosis↑, EstroRS/ERS↑, eff↑, *cardioP↑, *antiOx↑, *Inflam↓,
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Apoptosis↑, Dose↝, other↑, BloodF↓, VEGF↓, UroPA↓, PPARα↓, DR4↑, Casp3↑, PPARγ↑, antiNeop↑, Risk↓, 6IL↑,
7680- iod,  doxoR,    Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection
- vitro+vivo, BC, NA
antiNeop↑, antiOx↑, Dose↝, TumVol↓, PCNA↓, Weight↑, cardioP↑, ChemoSen↑,
7684- iod,    Molecular iodine impairs chemotherapy resistance and adverse effects in breast cancer treatments
- Trial, BC, NA
Dose↝, OS↑, antiNeop↑, eff↑,
7687- iod,  ESWT,    Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts
- in-vivo, BC, MDA-MB-231
antiNeop↑, CSCsMark↓, CD44↓, SOX2↓, HIF-1↓, VEGF↓, Dose↝, Dose↝, EPR↝, PPARγ↑,
7654- IP,    Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations
- in-vivo, BC, NA
TumCG↓, GutMicro↑, PA↑, HDAC2↓, HDAC8↓, DNMT3B↓, Akt↓, PI3K↓, NF-kB↓, Dose↝, Dose↝,
7655- IP,  SFN,    Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
- in-vivo, BC, NA
Dose↝, TumCG↓, TumW↓, GutMicro↑, HDAC↓, DNMTs↓, Akt↓, PI3K↓, mTOR↓, NF-kB↓, TumCCA↑, cl‑Casp3↑, cl‑Casp7↑, CDK2↓, CDK4↓, Risk↓, Dose↝,
7640- IP6,  Ins,    Effects of Inositol Hexaphosphate and Myo-Inositol Administration in Breast Cancer Patients during Adjuvant Chemotherapy
- Trial, BC, NA
*antiOx↑, QoL↑, RBC↑, HemoG↑, WBC↑, chemoP↑, Dose↝,
7739- isoFl,    Soy, red clover, and isoflavones and breast cancer: a systematic review
- Review, BC, NA
Dose↝, Risk↓, toxicity↓,
8170- Lap,  capec,    A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses
- Trial, BC, NA
Dose↝, TTP↑, OS↑,
8177- Las,    Lasiokaurin Regulates PLK1 to Induce Breast Cancer Cell G2/M Phase Block and Apoptosis
- vitro+vivo, BC, MDA-MB-231
Dose↝, tumCV↓, Apoptosis↑, TumCCA↑, PLK1↓, CDC25↓, Akt↓,
8264- LE,  ISL,    Glycyrrhiza glabra L. Extracts with Potential Antiproliferative and Anti-Migration Activities Against Breast and Gynecological Cancer Cell Lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, A2780S - in-vitro, Cerv, HeLa
eff↑, Dose↝, Dose↑,
8195- LGE,    In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity
- vitro+vivo, BC, 4T1
TumCD↑, Dose↝, TumVol↓, cl‑Casp3↑, β-catenin/ZEB1↑, ALDH↓, Wnt↓,
5242- MFrot,    Rotating magnetic field downregulating type XI collagen to suppress triple-negative breast cancer metastasis by inactivating the ITGB1/FAK/YAP signaling pathway
- in-vitro, BC, NA
TumCI↓, COL11A1↓, TumCG↓, TumMeta↓, ITGB1↓, FAK↓, YAP/TEAD↓, Dose↝,
5599- NaHCO3,    Acidity generated by the tumor microenvironment drives local invasion
- in-vivo, BC, MDA-MB-231 - in-vitro, CRC, HCT116
e-pH↑, TumCG↓, TumCI↓, Dose↝,
5602- NaHCO3,  immuno,    Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
- in-vivo, BC, 4T1
eff↑, TumCG↓, OS↑, e-pH↑, IFN-γ↑, IL2↑, IL12↑, Dose↝, PD-L1↓,
7431- Poly,    Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression
- vitro+vivo, BC, 4T1
other↝, AntiTum↑, Dose↝, TumCG↓, ALAT↓, AST↓, hepatoP↑, COX2/PTGS2↓, MMP2↓, MMP9↓,
7381- RS,    In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
- in-vitro, BC, MCF7
AntiCan↑, Apoptosis↑, DNAdam↑, Bcl-2↓, TGF-β↓, Dose↝,

Showing Research Papers: 1 to 50 of 58
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 58

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0)

2/16-OHE1↑, 1,   6IL↑, 1,   CR↑, 1,   miR-199↓, 1,   miR-542↓, 1,   Nausea↓, 1,   Nausea∅, 1,   PA↑, 1,   RBC↑, 2,   TTP↑, 1,   Vomit↓, 1,   Vomit∅, 1,   WBC↑, 1,  

Redox & Oxidative Stress(tgid=1)

antiOx↑, 2,   ROS↑, 4,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

CDC25↓, 1,  

Core Metabolism/Glycolysis(tgid=4)

ALAT↓, 1,   AMPK↓, 1,   cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   PPARα↓, 1,   PPARγ↑, 2,   SIRT2↓, 1,  

Cell Death(tgid=5)

Akt↓, 4,   Apoptosis↑, 9,   Apoptosis∅, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 2,   Bcl-2↓, 3,   Casp3↑, 2,   cl‑Casp3↑, 4,   cl‑Casp7↑, 1,   DR4↑, 1,   lysoMP↑, 1,   TumCD↓, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7)

other↑, 1,   other↝, 3,   tumCV↓, 4,  

Autophagy & Lysosomes(tgid=9)

TumAuto↓, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↑, 2,   DNMT3B↓, 1,   DNMTs↓, 1,   GADD45A↑, 1,   P53↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11)

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   PLK1↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12)

ALDH↓, 1,   CD44↓, 1,   CSCsMark↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   IGFR↓, 1,   mTOR↓, 2,   PI3K↓, 3,   SOX2↓, 1,   STAT3↓, 1,   TOP1↓, 1,   TumCG↓, 11,   TumCG∅, 2,   Wnt↓, 1,  

Migration(tgid=13)

COL11A1↓, 1,   FAK↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TumCI↓, 4,   TumCMig↓, 2,   TumCP↓, 4,   TumMeta↓, 2,   UroPA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14)

EPR↝, 1,   HIF-1↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16)

cellSen?, 1,   COX2/PTGS2↓, 1,   IFN-γ↑, 1,   IL12↑, 1,   IL2↑, 1,   IL6↓, 1,   Imm↑, 2,   LTA/TNF-β↑, 1,   MCP1/CCL2↓, 1,   Neut↓, 1,   NF-kB↓, 2,   PD-L1↓, 1,  

Cellular Microenvironment(tgid=17)

e-pH↑, 2,  

Hormonal & Nuclear Receptors(tgid=20)

EstroRS/ERS↑, 1,  

Drug Metabolism & Resistance(tgid=21)

ChemoSen↑, 6,   ChemoSen∅, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 55,   eff↓, 2,   eff↑, 12,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 9,  

Clinical Biomarkers(tgid=22)

ALAT↓, 1,   AST↓, 1,   BloodF↓, 1,   EstroRS/ERS↑, 1,   GutMicro↑, 2,   HemoG↑, 1,   IL6↓, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 2,   antiNeop↑, 5,   antiNeop∅, 1,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   hepatoP↑, 1,   OS↑, 5,   Pain↓, 1,   QoL↑, 2,   Remission↑, 2,   Risk↓, 3,   toxicity↓, 4,   toxicity∅, 1,   TumVol↓, 4,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 147

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↑, 4,   ROS↓, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21)

Dose↝, 1,  

Functional Outcomes(tgid=23)

cardioP↑, 2,   chemoP↑, 2,   toxicity↓, 3,   toxicity↝, 1,  
Total Targets: 9

Scientific Paper Hit Count for: Dose, Dosage
6 iodine
5 Chemotherapy
3 Curcumin
3 Formononetin
3 Inositol
2 Silver-NanoParticles
2 Radiotherapy/Radiation
2 doxorubicin
2 Ginger/6-Shogaol/Gingerol
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Inulin Prebiotic
2 Bicarbonate(Sodium)
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Bicalutamide
1 Cat’s Claw
1 Coenzyme Q10
1 Docosahexaenoic Acid
1 Docetaxel
1 Ascorbyl Palmitate
1 Echinacea
1 Evodiamine
1 Fenbendazole
1 Fisetin
1 Paclitaxel/Taxol
1 Gallic acid
1 Cisplatin
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 α-Bisabolol / Chamomile oil
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Photodynamic Therapy
1 Metformin
1 Hyperthermia
1 HydroxyTyrosol
1 Indole-3-carbinol
1 Isobavachalcone
1 Extracorporeal Shock Wave Therapy
1 Sulforaphane (mainly Broccoli)
1 isoflavones
1 Lapatinib
1 capecitabine
1 Lasiodin
1 Licorice
1 Isoliquiritigenin
1 Lemongrass Extract/Citral
1 Magnetic Field Rotating
1 immunotherapy
1 Polyphenols
1 Rauwolfia serpentina/Indian Snakeroot
1 α-Santalol/Sandalwood oil
1 Selenium NanoParticles
1 chitosan
1 Resveratrol
1 Ellagic acid
1 Shikonin
1 Triphala
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:4
wNotes=0 sortOrder:rid,rpid

 

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