EPR Cancer Research Results

EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱
Source:
Type:
Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
7687- iod,  ESWT,    Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts
- in-vivo, BC, MDA-MB-231
antiNeop↑, CSCsMark↓, CD44↓, SOX2↓, HIF-1↓, VEGF↓, Dose↝, Dose↝, EPR↝, PPARγ↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCsMark↓, 1,   SOX2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↝, 1,   HIF-1↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:612  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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