PARK2 Cancer Research Results

PARK2, PARKIN: Click to Expand ⟱
Source:
Type:
PARKIN (also known as PARK2) is an E3 ubiquitin ligase that plays a crucial role in mitochondrial quality control, cell cycle regulation, and apoptosis. Although PARKIN is best known for its involvement in Parkinson’s disease, an increasing number of studies have investigated its role in cancer.
-PARKIN is recruited to damaged mitochondria, which are often sources of elevated ROS due to impaired electron transport chains.
-By targeting dysfunctional mitochondria for autophagic degradation (mitophagy), PARKIN helps to mitigate excessive ROS production, preserving cellular redox balance.

-Reduced PARKIN expression generally correlates with more aggressive disease and worse prognosis in various cancers, including breast, lung, colorectal, liver, and pancreatic cancers.
neuroblastoma, Neuroblastoma: Click to Expand ⟱
Neuroblastoma is a type of cancer that develops in immature nerve tissue, usually affecting kids under age 5.
Scientific Papers found: Click to Expand⟱
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   MDA↑, 1,   PARK2↑, 1,   ROS↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↑, 1,   PINK1↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   proCasp3↓, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   MitoP↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑mTOR↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↝, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: PARK2, PARKIN
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:40  Cells:%  prod#:%  Target#:1240  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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