PKA Cancer Research Results

PKA, protein kinase A: Click to Expand ⟱

Source:

Type:

Protein kinase A (PKA)
• PKA is composed of regulatory (R) and catalytic (C) subunits. Binding of cAMP to the regulatory subunits releases the catalytic subunits, which then phosphorylate target proteins.
– Increased PKA activity has been associated with the activation of downstream signaling pathways that promote cell growth and survival.
– Thus, the level of PKA activation (often indirectly inferred by phosphorylation status of downstream targets) can serve as a marker for tumor progression and treatment resistance.
– PKA does not act in isolation—it interacts with other signaling pathways (e.g., MAPK, PI3K/AKT).

ESCC, Oesophageal Squamous Cell Carcinoma: Click to Expand ⟱

Esophageal cancer is a growth of cells that starts in the esophagus.

Scientific Papers found: Click to Expand⟱

2408-

PTS,

Pterostilbene suppresses the growth of esophageal squamous cell carcinoma by inhibiting glycolysis and PKM2/STAT3/c-MYC signaling pathway

in-vitro,

ESCC,

TumCP↓, TumCMig↓, PKA↓, GlucoseCon↓, lactateProd↓, PKM2↓, STAT3↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1, GlucoseCon↓, 1, lactateProd↓, 1, PKM2↓, 1,

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,

Migration ⓘ

PKA↓, 1, TumCMig↓, 1, TumCP↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PKA, protein kinase A

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells