RANTES Cancer Research Results

RANTES, CCL5: Click to Expand ⟱

Source:

Type:

RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), also known as CCL5
• RANTES/CCL5 is a chemokine that plays a central role in recruiting immune cells—such as T cells, eosinophils, and monocytes—to sites of inflammation.
• In the tumor microenvironment, RANTES can influence immune cell infiltration, which may either support anti-tumor responses or, conversely, facilitate a pro-tumorigenic inflammatory milieu depending on the context.
• RANTES is involved in modulating angiogenesis, cell migration, and the deposition of extracellular matrix components. These processes can affect tumor progression and metastasis.

-In several cancer types—including breast, lung, and colorectal cancers—elevated RANTES expression has been associated with more aggressive tumor behavior and, in some instances, poorer prognosis.

ESCC, Oesophageal Squamous Cell Carcinoma: Click to Expand ⟱

Esophageal cancer is a growth of cells that starts in the esophagus.

Scientific Papers found: Click to Expand⟱

2481-

Ba,

Rad,

Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages

in-vitro,

ESCC,

Eca109

0, 20, 40, or 80 µmol/L

in-vitro,

ESCC,

KYSE150

12LOX↓, RadioS↑, Dose↝, RANTES↓, MCP1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,

Immune & Inflammatory Signaling ⓘ

MCP1↓, 1, RANTES↓, 1,

Drug Metabolism & Resistance ⓘ

Dose↝, 1, RadioS↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: RANTES, CCL5

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells