PDGFRB Cancer Research Results

PDGFRB, Platelet-derived growth factor receptor beta: Click to Expand ⟱
Source:
Type:

PDGFRB is a true druggable receptor tyrosine kinase with relevance to tumor stroma, angiogenesis, pericytes, fibrosis, BBB integrity, and AD vascular dysfunction.

Field Suggested Entry
Target PDGFRB / PDGFR-β
Full Name Platelet-derived growth factor receptor beta
Target Class Receptor tyrosine kinase
Main Ligands PDGF-BB, PDGF-DD
Primary Biology Pericyte recruitment, vascular maturation, fibroblast activation, stromal remodeling, cell migration, proliferation, BBB maintenance
Cancer Relevance High: tumor stroma, angiogenesis, pericytes, CAFs, invasion, metastasis, therapy resistance
AD Relevance Medium-high: brain pericytes, blood-brain barrier integrity, neurovascular dysfunction, soluble PDGFRβ as a pericyte injury marker
Therapeutic Direction Context-dependent. In cancer, inhibition or stromal normalization may be useful. In AD, preservation/restoration of PDGFRβ signaling is likely protective.


ESCC, Oesophageal Squamous Cell Carcinoma: Click to Expand ⟱
Esophageal cancer is a growth of cells that starts in the esophagus.
Scientific Papers found: Click to Expand⟱
7999- itraC,    Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation
- vitro+vivo, ESCC, NA
AMPK↑, EGFR↓, PDGFRA↓, PDGFRB↓, Akt↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PDGFRA↓, 1,   PDGFRB↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDGFRB, Platelet-derived growth factor receptor beta
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:41  Cells:%  prod#:%  Target#:1495  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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