CHK1 Cancer Research Results

CHK1, Checkpoint Kinase 1: Click to Expand ⟱

Source:

Type:

A protein that plays a crucial role in the DNA damage response pathway. It is involved in the repair of DNA damage and the maintenance of genome stability.
CHK1 acts as a tumor suppressor by preventing the accumulation of DNA damage and maintaining genome stability. Loss of CHK1 function can lead to increased genetic instability and a higher risk of cancer.
-CHK1 is often overexpressed in various types of cancer, including breast, colorectal, lung, and ovarian cancer. Overexpression of CHK1 can contribute to the development of resistance to chemotherapy and radiation therapy.
-CHK1 expression is often higher in tumor cells compared to normal cells. This tumor-specific expression makes CHK1 a potential target for cancer therapy.

ESCC, Oesophageal Squamous Cell Carcinoma: Click to Expand ⟱

Esophageal cancer is a growth of cells that starts in the esophagus.

Scientific Papers found: Click to Expand⟱

251-

AL,

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

in-vitro,

ESCC,

Eca109

 0-100ug/ml

in-vitro,

ESCC,

EC9706

in-vivo,

NA,

5mg/kg/bw

mice

Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, BAX↑, 1, Casp3↑, 1, Casp9↑, 1, Cyt‑c↑, 1,

DNA Damage & Repair ⓘ

CHK1↑, 1, P53↑, 1,

Cell Cycle & Senescence ⓘ

CycB/CCNB1↓, 1, P21↑, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CHK1, Checkpoint Kinase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells