SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱

Source:

Type:

SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.

ESCC, Oesophageal Squamous Cell Carcinoma: Click to Expand ⟱

Esophageal cancer is a growth of cells that starts in the esophagus.

Scientific Papers found: Click to Expand⟱

1263-

CAP,

Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression

in-vitro,

ESCC,

Eca109

TumCMig↓, TumCI↓, MMP9↓, p‑AMPK↑, SIRT1↑, NF-kB↓, p‑IκB↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1, SIRT1↑, 1,

Migration ⓘ

MMP9↓, 1, TumCI↓, 1, TumCMig↓, 1,

Immune & Inflammatory Signaling ⓘ

p‑IκB↑, 1, NF-kB↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells