NCOA4 Cancer Research Results

NCOA4, Nuclear Receptor Coactivator 4: Click to Expand ⟱
Source:
Type:
NCOA4 (Nuclear Receptor Coactivator 4) is a protein that was initially characterized as a coactivator for nuclear receptors, enhancing transcriptional activity in response to ligands such as hormones.
Beyond transcriptional coactivation, NCOA4 is also known for its role in selective autophagy, particularly in mediating ferritinophagy (the autophagic degradation of ferritin), thus influencing cellular iron homeostasis.
Dysregulation of NCOA4 and its impact on iron metabolism may contribute to tumor progression, where a delicate balance between proliferation and cell death is maintained.
ESCC, Oesophageal Squamous Cell Carcinoma: Click to Expand ⟱
Esophageal cancer is a growth of cells that starts in the esophagus.
Scientific Papers found: Click to Expand⟱
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   Iron↑, 2,   MDA↑, 1,   ROS↑, 1,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,   NCOA4↑, 1,   TfR1/CD71↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   ATG7↑, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: NCOA4, Nuclear Receptor Coactivator 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:41  Cells:%  prod#:%  Target#:985  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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