TSHR Cancer Research Results

TSHR, thyroid stimulating hormone receptor: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
The thyroid-stimulating hormone receptor (TSHR) is a G protein-coupled receptor that plays a crucial role in regulating thyroid function by mediating the effects of thyroid-stimulating hormone (TSH) on the thyroid gland. TSHR is primarily involved in the synthesis and release of thyroid hormones.
The TSHR gene encodes the thyroid-stimulating hormone receptor (TSHR), which is a G protein-coupled receptor located on the surface of thyroid follicular cells. This receptor is crucial for the regulation of thyroid hormone synthesis and secretion in response to thyroid-stimulating hormone (TSH), which is produced by the pituitary gland.

TSHR expression is well established as a marker of differentiation and prognosis in thyroid cancer, with lower levels generally indicating a worse prognosis.

More aggressive thyroid cancers (poorly differentiated or anaplastic thyroid carcinoma) may show reduced or lost TSHR expression, which is associated with a worse prognosis.
Thyroid, Thyroid: Click to Expand ⟱
Thyroid


Scientific Papers found: Click to Expand⟱
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, VEGF↓, Imm↑, NK cell↑, eff↑, PI3K↓, Akt↓, EMT↓, MAPK↓, Wnt↓, NF-kB↓, IRes↓, *ROS↓, TumVol↓, *TSHR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IRes↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   PI3K↓, 1,   Wnt↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   NF-kB↓, 1,   NK cell↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 3

Scientific Paper Hit Count for: TSHR, thyroid stimulating hormone receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:43  Cells:%  prod#:%  Target#:319  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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