miR-221 Cancer Research Results

miR-221, miR-221: Click to Expand ⟱

Source:

Type:

miR-221 (usually discussed together with miR-222) is a context-dependent, predominantly oncogenic microRNA that promotes cell-cycle progression, EMT, invasion, therapy resistance, and immune evasion in many cancers. Unlike miR-15/101/206, miR-221 is often overexpressed rather than lost.
-In Cancer: frequently upregulated

OS, Osteosarcoma: Click to Expand ⟱

Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.

Scientific Papers found: Click to Expand⟱

5727-

BF,

Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221

in-vitro,

OS,

U2OS

TumCP↓, Apoptosis↑, ROS↑, miR-221↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ROS↑, 1,

Cell Death ⓘ

Apoptosis↑, 1,

Migration ⓘ

miR-221↓, 1, TumCP↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-221, miR-221

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells