Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
OS, Osteosarcoma: Click to Expand ⟱
Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.
Scientific Papers found: Click to Expand⟱
1290- AL,    Bcl-2_and_Bax_protein_in_LM-8_cells">Effect of allicin on the expression of Bcl-2 and Bax protein in LM-8 cells
- in-vitro, OS, LM8
Bcl-2↓, BAX↑, Apoptosis↑, TumCG↓,
1523- Ba,    Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- NA, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
6334- Cro,  Eug,  Rad,    Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro
- in-vitro, OS, NA
tumCV↓, RadioS↑, TumCCA↑, BAX↑, Casp3↑, Bcl-2↓, cycA1/CCNA1↓, CycB/CCNB1↓,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
6990- Form,    Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo
- vitro+vivo, OS, U2OS
TumCP↓, Apoptosis↑, Bcl-2↓, miR-375↓, BAX↑,
7033- GA,  OL,    Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line
- in-vitro, OS, U2OS
tumCV↓, angioG↓, DNAdam↑, Apoptosis↑, cl‑PARP↓, Bcl-2↓, BAX↑, ROS↓, eff↑, TumCMig↓, VEGF↓, Casp9↑, P53↑, selectivity↑,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,
7796- ISQ,    Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,
2048- PB,    Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo
- in-vitro, OS, CAL27 - in-vitro, Oral, HSC3 - in-vitro, OS, SCC4 - in-vivo, NA, NA
*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, eff↑,
52- QC,    Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines
- in-vitro, BC, MCF7 - in-vitro, Ovarian, SKOV3 - in-vitro, OS, U2OS
Bcl-2↓, BAX↑, PI3K/Akt↓, cycD1/CCND1↓, TumCCA↑,
1312- SK,    Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells
- in-vitro, OS, 143B
ROS↑, p‑ERK↑, Bcl-2↓, cl‑PARP↑, Apoptosis↑, TumCCA↑, Bcl-2↑, proCasp3↓,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   ROS↓, 1,   ROS↑, 8,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 4,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDH?, 1,   PI3K/Akt↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis?, 1,   Apoptosis↑, 12,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 9,   Bcl-2↓, 15,   Bcl-2↑, 1,   Bcl-xL↓, 3,   Casp3↑, 6,   cl‑Casp3↑, 3,   proCasp3↓, 1,   Casp8↑, 1,   Casp9↑, 3,   Cyt‑c↑, 4,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   p‑p38↑, 1,   survivin↓, 1,   TRPV1↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 2,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   BNIP3?, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   p‑ERK↑, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   mTORC1↓, 1,   PI3K↓, 2,   PTEN↑, 1,   STAT3↓, 1,   STAT3↑, 1,   TumCG↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   Ca+2↝, 1,   cal2↑, 1,   E-cadherin↑, 2,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 2,   TGF-β↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 2,   Twist↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IKKα↑, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 1,   JAK1↑, 1,   NF-kB↓, 3,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 2,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   LDH?, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 94

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NH3↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
1 Allicin (mainly Garlic)
1 Baicalein
1 Beta-Caryophyllene
1 Capsaicin
1 Crocetin
1 Eugenol
1 Radiotherapy/Radiation
1 Fisetin
1 Formononetin
1 Gallic acid
1 olaparib/LYNPARZA
1 Honokiol
1 Hyperthermia
1 isoquercitrin
1 Phenylbutyrate
1 Quercetin
1 Shikonin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:46  Cells:%  prod#:%  Target#:27  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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