GSR Cancer Research Results

GSR, Glutathione Reductase: Click to Expand ⟱

Source:

Type:

Glutathione reductase is an enzyme that plays a crucial role in maintaining the balance of glutathione, a powerful antioxidant found in cells. Glutathione is involved in various cellular processes, including detoxification, cell signaling, and protection against oxidative stress. Glutathione reductase helps maintain the levels of reduced glutathione (GSH) in cells. Cancer cells often have elevated levels of glutathione reductase, which allows them to maintain high levels of GSH and resist oxidative stress.
Glutathione reductase has been shown to promote cell proliferation and survival in cancer cells. Elevated levels of glutathione reductase have been found in various types of cancer, including breast, lung, and colon cancer.
Several studies have shown that inhibiting glutathione reductase can increase the sensitivity of cancer cells to chemotherapy and radiation therapy, and may also induce apoptosis in cancer cells.

OS, Osteosarcoma: Click to Expand ⟱

Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.

Scientific Papers found: Click to Expand⟱

1477-

SFN,

Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling

in-vitro,

OS,

MG63

>10 μM

tumCV↓, Apoptosis↑, Casp3↑, ROS↑, GSR↓, GPx↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GPx↓, 1, GSR↓, 1, ROS↑, 1,

Cell Death ⓘ

Apoptosis↑, 1, Casp3↑, 1,

Transcription & Epigenetics ⓘ

tumCV↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GSR, Glutathione Reductase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells