MDR1 Cancer Research Results

MDR1, Multidrug Resistance 1: Click to Expand ⟱
Source:
Type: gene
MDR-1 (Multidrug Resistance 1) is a gene that plays a crucial role in the development of resistance to chemotherapy in cancer cells. The MDR-1 gene encodes for a protein called P-glycoprotein (P-gp), which is a transmembrane efflux pump that helps to remove toxic substances, including chemotherapy drugs, from cells.
MDR-1 is often overexpressed in various types of cancer, including: Leukemia, Lymphoma, Breast, Lung, Ovarian, CRC.
OS, Osteosarcoma: Click to Expand ⟱
Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.
Scientific Papers found: Click to Expand⟱
5965- CEL,  Cisplatin,    Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
- in-vitro, OS, MG63
COX2↓, ChemoSen↑, MDR1↓, MRP1↓, E-cadherin↓, β-catenin/ZEB1↓, Apoptosis↑, TumCCA↑, TumCG↓, P-gp↓, PI3K↓, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   β-catenin/ZEB1↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   MDR1↓, 1,   MRP1↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MDR1, Multidrug Resistance 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:46  Cells:%  prod#:%  Target#:741  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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