cal2 Cancer Research Results

cal2, calpain-2: Click to Expand ⟱
Source:
Type:
Calpain-2 is a calcium-dependent cysteine protease that plays important roles in a variety of cellular processes, including migration, adhesion, signal transduction, and apoptosis.
In many cancer types, Calpain-2 is found to be upregulated. Elevated levels of Calpain-2 have been associated with enhanced proteolytic activity, which can contribute to cancer progression by facilitating processes such as cell migration, invasion, and metastasis.
• The increased expression of Calpain-2 in cancer cells can promote the degradation of cytoskeletal and adhesion proteins, thereby aiding in tumor cell detachment and dissemination. This is particularly relevant during epithelial-to-mesenchymal transition (EMT) and remodeling of the extracellular matrix.
• Calpain-2 activity, which is regulated by intracellular Ca²⁺ levels and calpastatin (its endogenous inhibitor), may also influence signal transduction pathways that are critical for cell proliferation and survival. Alterations in these regulatory mechanisms in a tumor setting can amplify Calpain-2’s impact.

Calpain-2 is commonly upregulated in many cancer types, and this increased expression is thought to promote tumor progression by enhancing cellular invasiveness, migration, and survival through its proteolytic actions.
OS, Osteosarcoma: Click to Expand ⟱
Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.
Scientific Papers found: Click to Expand⟱
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bak↑, 1,   BAX↓, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Migration ⓘ

Ca+2↝, 1,   cal2↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cal2, calpain-2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:46  Cells:%  prod#:%  Target#:1000  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page