cellSen Cancer Research Results

cellSen, cellular senescence: Click to Expand ⟱
Source:
Type:
Cellular senescence is a state in which cells cease to divide and grow, often in response to DNA damage or other forms of cellular stress.
On one hand, senescence can prevent cancer by:
-Halting the proliferation of damaged cells, thereby preventing the accumulation of mutations that can lead to cancer
-Activating immune responses that can eliminate senescent cells.
-Producing anti-tumor factors that can inhibit the growth of nearby cancer cells.

On the other hand, senescence can also promote cancer by:
-Creating a pro-tumorigenic microenvironment that can support the growth of nearby cancer cells
-Producing pro-inflammatory factors that can promote cancer progression
-Contributing to the development of a senescence-associated secretory phenotype (SASP), which can promote cancer cell growth and metastasis.
OS, Osteosarcoma: Click to Expand ⟱
Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.
Scientific Papers found: Click to Expand⟱
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   p‑CHK1↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling ⓘ

cellSen↑, 1,   CXCR2↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cellSen, cellular senescence
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:46  Cells:%  prod#:%  Target#:920  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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