5LO Cancer Research Results

5LO, 5-lipoxygenase (5-LO): Click to Expand ⟱
Source:
Type:
5‑Lipoxygenase (5‑LO) is an enzyme that catalyzes the oxygenation of arachidonic acid to produce leukotrienes and other bioactive lipid mediators. It is a member of the lipoxygenase family and plays a key role in inflammatory responses.

5‑LO is overexpressed in various malignancies, particularly those with a strong inflammatory component.
Overexpression of 5‑LO is often detected in tumor cells as well as in stromal cells (e.g., tumor-associated macrophages) within the tumor microenvironment.
Elevated 5‑LO expression is frequently linked with increased tumor proliferation, enhanced angiogenesis, and higher metastatic potential—factors that often correlate with a poor prognosis.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
1421- Bos,    Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes
- in-vitro, AML, HL-60 - in-vitro, Nor, NA
ROS↑, NADPH↝, 5LO↓, Ca+2↑, p38↑, p42↑,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, asthmatic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *eff↑, *BChE↓, *CRP↓,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

p42↑, 1,  

Core Metabolism/Glycolysis ⓘ

NADPH↝, 1,  

Cell Death ⓘ

Casp3↑, 1,   Casp9↑, 1,   p38↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 2,   Ca+2↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   TumCI↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   NF-kB↓, 1,   NK cell↑, 1,   PGE2↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Kinase & Signal Transduction ⓘ

TRPV3↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

5LO↓, 3,   AntiAg↑, 2,   Ca+2↑, 1,   ZO-1↑, 1,  

Barriers & Transport ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 3,   NF-kB↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv⇅, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   chemoPv↑, 2,   cognitive↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   Obesity↓, 1,   Pain↓, 1,   Risk↓, 1,   toxicity↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Diar↓, 1,  
Total Targets: 49

Scientific Paper Hit Count for: 5LO, 5-lipoxygenase (5-LO)
1 Aloe anthraquinones
1 Boswellia (frankincense)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Chocolate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1090  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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