CYP2C9 Cancer Research Results

CYP2C9, CYP2C9: Click to Expand ⟱
Source:
Type:
CYP2C9, cytochrome P450 enzyme
– CYP2C9 is involved in the metabolism of a range of xenobiotics, including several anticancer drugs, which can affect drug efficacy and toxicity.
– Although CYP2C9 is not traditionally considered an oncogene or tumor suppressor, its expression and genetic variants can influence patient responses to chemotherapy.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, eff↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
5480- BM,    Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents
- Human, Nor, NA
P450↓, CYP3A4↓, CYP2C9↓,
8217- LCA,    Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
- Study, Nor, NA
*CYP1A1↓, *CYP2C19↓, *CYP2C8↓, *CYP2C9↓, *CYP3A4↓, *CYP2E1↓, *CYP2D6↓, *BioEnh↑, eff↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP3A4↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

CYP1A2↓, 1,   CYP2C9↓, 2,   Dose∅, 1,   eff↑, 2,   Half-Life∅, 1,   P450↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CYP2C19↓, 1,   CYP2C8↓, 1,   CYP2D6↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,   CYP2E1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP3A4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioEnh↑, 1,   CYP2C9↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: CYP2C9, CYP2C9
1 Apigenin (mainly Parsley)
1 Bacopa monnieri
1 Licochalcone A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1130  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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