CYP3A4 Cancer Research Results

CYP3A4, CYP3A4: Click to Expand ⟱
Source:
Type:
CYP3A4 is the most abundant cytochrome P450 enzyme in the liver and is also expressed in extrahepatic tissues.
– It metabolizes a wide range of drugs and endogenous substrates, including hormones.

– In some studies, higher CYP3A4 expression has been correlated with poorer response to treatment and potentially worse survival.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, eff↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
5718- BF,    Bufalin inhibits CYP3A4 activity in vitro and in vivo
- in-vivo, Nor, NA
CYP3A4↓, Apoptosis↑, AntiTum↑,
5480- BM,    Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents
- Human, Nor, NA
P450↓, CYP3A4↓, CYP2C9↓,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5714- Brut,    Probable Interaction of Bergamottin and Cyclosporine in a Lung Transplant Recipient
- Case Report, Nor, NA
*CYP3A4↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

CYP3A4↓, 3,  

Cell Death ⓘ

Apoptosis↑, 1,  

Drug Metabolism & Resistance ⓘ

CYP1A2↓, 1,   CYP2C9↓, 2,   Dose∅, 1,   eff↑, 1,   Half-Life∅, 1,   P450↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

CYP3A4↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioEnh↑, 1,   eff↑, 2,   Half-Life↝, 1,  

Functional Outcomes ⓘ

neuroP↑, 2,   toxicity↝, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: CYP3A4, CYP3A4
1 Apigenin (mainly Parsley)
1 Bufalin/Huachansu
1 Bacopa monnieri
1 borneol
1 Bruteridin(bergamot juice)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1131  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page