HMGCR Cancer Research Results

HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR): Click to Expand ⟱
Source:
Type:
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
– HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a critical step in the cholesterol biosynthesis pathway.
– Cholesterol is essential for maintaining cell membrane integrity and serves as a precursor for steroid hormones, which can influence tumor growth.

– In certain contexts, elevated HMGCR expression has been linked to more aggressive tumor phenotypes, increased proliferation, and, in some cases, poorer overall survival.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
1544- Api,    The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68
- in-vitro, Nor, WRL68
*SREBF2↓, *HMGCR↓, *Dose∅, *BioAv?,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↓, 1,   p‑AMPK↑, 1,   LDL↓, 1,   lipidLev↓, 1,   PPARγ↓, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Fas↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HMGCR↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   Dose∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Obesity↓, 1,   Weight↓, 1,  
Total Targets: 15

Scientific Paper Hit Count for: HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1133  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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