tyrosinase Cancer Research Results

tyrosinase, tyrosinase: Click to Expand ⟱
Source:
Type:
Tyrosinase expression has been evaluated in various cancers—primarily melanoma—and its association with prognosis.
Tyrosinase and Cancer — Melanocytic Lineage Enzyme, Differentiation Marker, and Selective Target
Melanin Synthesis, Lineage Marker, and Therapeutic Handle

– Tyrosinase is normally expressed in melanocytes and is generally maintained in melanomas.
– Elevated tyrosinase expression in blood (detectable tyrosinase mRNA) has been correlated with advanced disease stage and the presence of micrometastases.
Direction of Regulation in Cancer
-Context-specific, but most informative in melanoma:
-Upregulated in differentiated melanocytic tumors
-Downregulated or lost in dedifferentiated, invasive, therapy-resistant melanoma states

Thus, tyrosinase is best read as a lineage/differentiation marker, not a universal oncogenic driver.


Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
4858- Uro,    The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent
- in-vitro, Nor, NA
*ROS?, *neuroP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *monoA↓, *tyrosinase↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   GSR↑, 1,   lipid-P↓, 1,   ROS?, 1,   SOD↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

tyrosinase↓, 1,  

Synaptic & Neurotransmission ⓘ

monoA↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: tyrosinase, tyrosinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1160  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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