TXNIP Cancer Research Results

TXNIP, TBP-2: Click to Expand ⟱
Source:
Type:
TXNIP {TBP-2 (Thioredoxin Binding Protein-2)} is broadly considered a tumor suppressor, given its roles in redox regulation, apoptosis, and cellular metabolism.
- Thioredoxin‐interacting protein (TXNIP), which belongs to the arrestin family and is induced by various stimuli, interacts with and inhibits thioredoxin activity.

- Lower TXNIP expression has been correlated with more aggressive disease features and poorer prognosis, while higher expression tends to associate with less aggressive phenotypes.
- A consistent theme across these cancers is that lower TXNIP expression frequently correlates with more aggressive disease and a worse prognosis.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3225- EGCG,    Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway
- in-vitro, Nor, NA - in-vivo, Nor, NA
*RenoP↑, *NLRP3↓, *TXNIP↓, *ASC↓, *Casp1↓, *IL1β↓, *ROS↓, *TNF-α↓, *IL6↓, *IL18↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp8↑, 1,   Fas↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   TNF-α↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   PPARα↑, 1,   SIRT1↑, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Casp1↓, 2,   iNOS↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,  

Migration ⓘ

TXNIP↓, 2,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   IFN-γ↓, 1,   IL18↓, 2,   IL1β↓, 2,   IL2↓, 1,   IL6↓, 2,   Inflam↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

hepatoP↑, 1,   RenoP↑, 1,  
Total Targets: 36

Scientific Paper Hit Count for: TXNIP, TBP-2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1237  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page