HIF2a Cancer Research Results

HIF2a, Hypoxia-Inducible Factor 2 alpha: Click to Expand ⟱
Source:
Type:
HIF-2α (Hypoxia-Inducible Factor 2 alpha), also known as EPAS1, is a transcription factor that plays a key role in the cellular response to hypoxia (low oxygen conditions). In cancer, HIF-2α is involved in regulating genes that promote angiogenesis, metabolism, cell proliferation, and survival.

-Tumors often experience hypoxia due to rapid cell growth outpacing vascular supply. This leads to the stabilization and upregulation of HIF-2α.
-Elevated HIF-2α expression has been observed in several cancer types, including renal cell carcinoma, glioma, lung, breast, and colorectal cancers.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3000- PL,    Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
- in-vitro, Nor, HUVECs - in-vitro, Laryn, HEp2
Inflam↓, AntiTum↑, *α-tubulin↓, selectivity↑, HIF2a↓, MCP1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Angiogenesis & Vasculature ⓘ

HIF2a↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   MCP1↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Migration ⓘ

α-tubulin↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: HIF2a, Hypoxia-Inducible Factor 2 alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1274  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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