MCU Cancer Research Results

MCU, mitochondrial calcium uniporter: Click to Expand ⟱

Source:

Type:

Mitochondrial calcium uniporter (MCU) is a highly selective channel complex located in the inner mitochondrial membrane.
-MCU facilitates the uptake of calcium (Ca²⁺) into the mitochondrial matrix, a process that is crucial for regulating mitochondrial metabolism, cell signaling, and apoptosis.
-Mitochondrial Ca²⁺ uptake via MCU plays a key role in stimulating metabolic enzymes in the tricarboxylic acid (TCA) cycle, thereby influencing energy production.

-Overexpression of MCU has been linked in some studies to enhanced Ca²⁺ uptake, metabolic changes, and increased tumor cell migration.
-In this context, higher MCU levels (or enhanced activity) have been associated with more aggressive tumor behavior and poorer outcomes, although findings may vary with tumor subtype.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

2684-

BBR,

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

in-vivo,

Nor,

mice

*MCU↓, *mt-Ca+2↓, *cardioP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

MCU↓, 1,

Migration ⓘ

mt-Ca+2↓, 1,

Functional Outcomes ⓘ

cardioP↑, 1,
Total Targets: 3

Scientific Paper Hit Count for: MCU, mitochondrial calcium uniporter

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells