IL12 Cancer Research Results

IL12, Interleukin-12: Click to Expand ⟱
Source: HalifaxProj(induce)
Type:
IL-12, an antitumor cytokine is considered to be a promising cytokine for enhancing an antitumor immune response.
Interleukin-12 (IL-12) is a cytokine that plays a crucial role in the immune response, particularly in the activation of T cells and natural killer (NK) cells. It is produced by various immune cells, including macrophages and dendritic cells, and is known for its ability to promote the differentiation of T cells into a type that can effectively combat cancer cells.

IL-12 is often expressed in various cancers, including melanoma, renal cell carcinoma, breast cancer, and colorectal cancer. Its expression can vary depending on the tumor type and the immune context.
Tumor-infiltrating immune cells, particularly activated macrophages and dendritic cells, are significant sources of IL-12 in the tumor microenvironment.

IL-12 is primarily known for its role in promoting anti-tumor immunity. It enhances the differentiation of naive T cells into T helper 1 (Th1) cells, which produce pro-inflammatory cytokines and support cytotoxic T cell responses.
IL-12 also stimulates the activity of NK cells, enhancing their ability to kill tumor cells and produce additional cytokines, such as interferon-gamma (IFN-γ), which further promotes anti-tumor immunity.

Low levels of IL-12 in the tumor microenvironment are often associated with poor anti-tumor immune responses and can correlate with worse clinical outcomes. In such cases, strategies to enhance IL-12 production or signaling may be beneficial for improving anti-tumor immunity.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
5119- JG,    Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice
- in-vivo, Nor, NA
*antiOx↑, *OS↑, *IL6↓, *IL12↓, *IL23↓, *TNF-α↓, *Inflam↓, *NF-kB↓, *NFE2L2↓, *ROS↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx↑, 1,   GSR↑, 1,   HO-1↑, 1,   MDA↓, 1,   NFE2L2↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Migration ⓘ

E-sel↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL10↑, 2,   IL12↓, 2,   IL17↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL23↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 31

Scientific Paper Hit Count for: IL12, Interleukin-12
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:157  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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