β-HEX Cancer Research Results

β-HEX, β-hexosaminidase Release: Click to Expand ⟱

Source:

Type:

β-Hexosaminidase Release

Abbreviation: β-HEX Release

Type: Mast-cell/basophil degranulation biomarker / functional outcome

Function: β-Hexosaminidase is a lysosomal enzyme stored in secretory granules of mast cells and basophils. Following activation, including IgE-FcεRI-mediated stimulation, β-hexosaminidase is released together with other granule mediators. Measurement of extracellular β-hexosaminidase activity is therefore widely used as a quantitative marker of mast-cell and basophil degranulation.

Asthma / Allergy: ↑ Increased β-hexosaminidase release indicates increased mast-cell or basophil degranulation and is associated with greater allergic mediator release. It is commonly used as an experimental endpoint for IgE-mediated allergic activation.

Favorable Direction in Asthma / Allergy: ↓ β-Hexosaminidase release is favorable and indicates reduced mast-cell/basophil degranulation and antiallergic activity.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

8154-

lamb,

Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells

in-vitro,

Nor,

*IL6↓, *PGD2↓, *LTC4↓, *COX2/PTGS2↓, *β-HEX↓, *antiAll↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

antiAll↑, 1, LTC4↓, 1, β-HEX↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1, IL6↓, 1, PGD2↓, 1,

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,
Total Targets: 7

Scientific Paper Hit Count for: β-HEX, β-hexosaminidase Release

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells