mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
1565- Api,    Apigenin-7-glucoside induces apoptosis and ROS accumulation in lung cancer cells, and inhibits PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1975
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, Cyt‑c↑, MDA↑, GSH↓, ROS↑, PI3K↓, Akt↓, mTOR↓,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
6622- Cic,    Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans
- in-vivo, Nor, NA
*ROS↓, *AMPK↑, *GPx↑, *SOD↑, *SOD2↑, *PGC-1α↑, *Akt↓, *mTOR↓, *Insulin↓, *antiOx↑, *AntiAge↑,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
5068- dietSTF,    mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation
- in-vivo, Nor, NA
*glucose↓, ROS↑, LC3B↑, p62↓, p‑mTOR↓, p‑AMPK↑,
3214- EGCG,    EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway
- in-vitro, Nor, MRC-5 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
mTOR↓, AMPK↑, selectivity↑, ROS↑, selectivity↑, HO-1↓, *NRF2↑, NRF2↓, *HO-1↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6914- FIS,    Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells
- in-vitro, Nor, RAW264.7
*p‑PI3K↓, *p‑Akt↓, *p‑mTOR↓,
7252- Gink,    STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells
- in-vitro, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, SV-HUC-1
tumCV↓, selectivity↑, TumCMig↓, EMT↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, STEAP3↓, Bax:Bcl2↑, cl‑Casp3↑,
2892- HNK,    Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, H385 - in-vitro, Nor, BEAS-2B
TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
7553- HYP,    Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro
- in-vitro, NSCLC, A549 - in-vitro, Nor, BEAS-2B
LC3II↑, selectivity↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, p‑4E-BP1↓, p‑ERK↑, tumCV↓, Apoptosis↑,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7982- itraC,    Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
- in-vitro, Nor, HUVECs - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293
angioG↓, mTOR↓, NPC1L1↓, AMPK↑, VDAC1↓,
7983- itraC,    Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
- in-vitro, Nor, HUVECs
angioG↓, VDAC1↓, mt-ATP↓, AMPK↑, mTOR↓, TumCP↓,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,
3265- Lyco,    Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- in-vitro, Nor, NA
*AMPK↑, *mTOR↓, *NLRP3↓, *Pyro↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
3186- SFN,    A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
- in-vivo, Nor, NA
*NLRP3↓, *ASC↓, *Casp1↓, *IL1β↓, *ALAT↓, *AST↓, *AMPK↑, *mTOR↓, *P70S6K↓,

Showing Research Papers: 1 to 28 of 28

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 28

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 2,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 3,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   Iron↓, 1,   Iron↑, 3,   lipid-P↑, 1,   MDA↑, 3,   NADPH/NADP+↓, 1,   NRF2↓, 2,   ROS↑, 8,   SIRT3↑, 1,   VDAC1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2,   NCOA4↑, 2,   STEAP3↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   mt-ATP↓, 1,   MMP↓, 1,   mtDam↑, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 4,   p‑AMPK↑, 2,   ATG7↑, 1,   glucose↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 3,   LDH↓, 1,   NPC1L1↓, 1,   PFKP↓, 1,   PKM2↓, 1,   Pyruv↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 5,   Apoptosis?, 1,   Apoptosis↑, 8,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   Ferroptosis↑, 2,   MAPK↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   HER2/EBBR2↓, 1,   miR-25-5p↓, 1,   p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3II↑, 2,   p62↓, 2,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 2,   Securin↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   EMT↓, 3,   p‑ERK↑, 1,   mTOR↓, 13,   p‑mTOR↓, 6,   p‑P70S6K↓, 1,   PI3K↓, 5,   p‑PI3K↓, 2,   PTEN↑, 1,   STAT3↓, 2,   TCF↓, 1,   TumCG↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP7↓, 2,   MMP9↓, 1,   Smad1↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 9,   TumMeta↓, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   ATF4↑, 1,   EGFR↓, 2,   Endoglin↑, 1,   Hif1a↓, 4,   VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   JAK↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   PSA↓, 1,   SOCS-3↑, 1,   TLR4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↑, 2,   Dose↝, 1,   eff↓, 2,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   TumVol↓, 2,   TumW↓, 2,  
Total Targets: 140

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   AntiP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   GPx↑, 3,   GSH↑, 4,   GSR↑, 1,   HO-1↑, 4,   lipid-P↓, 1,   MDA↓, 2,   NQO1↑, 1,   NRF2↑, 7,   ROS↓, 4,   mt-ROS↓, 1,   SOD↑, 4,   SOD2↑, 1,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 6,   p‑AMPK↑, 1,   p‑CREB↑, 1,   FGF21↑, 1,   glucose↓, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↑, 1,   LDL↓, 1,   PFK↑, 1,   PKM2↑, 1,   PPARα↑, 1,   PPARγ↓, 2,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↓, 2,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp9↓, 1,   MAPK↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   GSK‐3β↓, 1,   IGF-1↓, 1,   mTOR↓, 7,   p‑mTOR↓, 3,   P70S6K↓, 2,   PI3K↓, 1,   p‑PI3K↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   TGF-β1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↑, 1,   Hif1a↓, 1,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 5,   Inflam↑, 1,   MyD88↓, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BMD↑, 1,   GutMicro↑, 5,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 6,   Obesity↓, 3,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,  
Total Targets: 111

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 itraconazole
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Berberine
1 Chrysin
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Calorie Restriction Mimetics
1 Curcumin
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Emodin
1 Ginkgetin
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 isoquercitrin
1 Isovitexin
1 Licochalcone A
1 Lactoferrin/Talactoferrin
1 Lycopene
1 Magnolol
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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