PDK1 / PDPK1 Cancer Research Results

PDK1 / PDPK1, Pyruvate dehydrogenase kinase 1: Click to Expand ⟱
Source:
Type:

PDPK1 - 3-Phosphoinositide-Dependent Protein Kinase 1

Abbreviation: PDPK1, PDK1

Type: Serine/threonine protein kinase / PI3K pathway signaling kinase / AGC kinase activator

Function: PDPK1 is a central signaling kinase downstream of phosphoinositide 3-kinase. It phosphorylates and activates multiple AGC-family kinases, including AKT, S6K, SGK, RSK, and selected PKC isoforms, thereby regulating proliferation, survival, metabolism, migration, and cellular growth.

Cancer: ↑ Frequently overexpressed, hyperactivated, or functionally dysregulated in cancer. Increased PDPK1 signaling enhances PI3K-AKT pathway output, proliferation, survival, migration, invasion, metastasis, metabolic adaptation, and resistance to anticancer therapies. Genetic or pharmacological suppression of PDPK1 can inhibit tumor growth and restore treatment sensitivity in experimental models.

Favorable Direction in Cancer: ↓ PDPK1 expression or kinase activity is generally favorable.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2473- BA,    Baicalin Inhibits EMT through PDK1/AKT Signaling in Human Nonsmall Cell Lung Cancer
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H460
EMT↓, PDK1 / PDPK1↓, Akt↓, TumCMig↓, E-cadherin↑, Vim↓,
6547- BSB,    Antitumor effects of a-bisabolol against pancreatic cancer
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, KLM1 - in-vitro, PC, KP4 - in-vitro, Nor, ACBRI515
TumCP↓, selectivity↑, Apoptosis↑, Akt↓, EGR1↑, TumCG↓, Dose↝, PI3K↓, PDK1 / PDPK1↓, mTORC2↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1 / PDPK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, BioAv↑, BioAv↑, BioAv↑,
2472- RES,    Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
- in-vivo, Nor, NA
*SIRT1↑, *PGC-1α↑, *cMyc↑, *PDK1 / PDPK1↓,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1 / PDPK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1 / PDPK1↓, BNIP3↓,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

mt-OXPHOS↓, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   citrate↓, 1,   ECAR↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 2,   LDHA↓, 1,   PDH↑, 1,   p‑PDH↑, 1,   PDK1 / PDPK1↓, 7,   PDKs↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Apoptosis↑, 3,   BAX↑, 1,   Bax:Bcl2↓, 1,   Casp↑, 2,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   TRAIL↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNA-PK↑, 1,   DNAdam↑, 1,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   mTOR⇅, 1,   mTORC2↑, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   TSC1↑, 1,   TumCMig↓, 1,   TumCP↓, 2,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGR1↑, 1,   Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   Dose↝, 1,   Dose∅, 2,   eff↑, 3,   selectivity↑, 3,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,   LDH↓, 2,  
Total Targets: 55

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↑, 1,   PDK1 / PDPK1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Pyro↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   IL8↓, 1,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioEnh↑, 1,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 1,   RenoP↑, 1,   toxicity∅, 1,  
Total Targets: 20

Scientific Paper Hit Count for: PDK1 / PDPK1, Pyruvate dehydrogenase kinase 1
2 Vitamin C (Ascorbic Acid)
1 Baicalin
1 α-Bisabolol / Chamomile oil
1 Dichloroacetate
1 Metformin
1 Ellagic acid
1 Isoliquiritigenin
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:246  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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