| Source: |
| Type: |
| Prostaglandin E2 (PGE2) is a lipid compound that plays a significant role in various physiological processes, including inflammation, immune response, and regulation of cell growth.
PGE2 is often found at elevated levels in various types of cancer, including colorectal, breast, and lung cancers. It can promote tumor growth by enhancing cell proliferation, inhibiting apoptosis (programmed cell death), and promoting angiogenesis (the formation of new blood vessels). - PGE2 is a pain-inducing factor. It is able to sensitize primary sensory neurons and leads to central sensitization and also facilitate the release of pain-related neuropeptides -Upregulated in AD brain; promotes inflammatory cytokine release, increase ROS, may increase Aβ deposition |
| Normal Healthy |
| 7146- | AL, | GI, | Eug, | CAP, | Herbal remedies and anticoagulant therapy |
| - | Review, | Nor, | NA |
| 5419- | ASTX, | Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications |
| - | Review, | Nor, | NA |
| 2686- | BBR, | Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs |
| - | Review, | Nor, | NA |
| 2749- | BetA, | Anti-Inflammatory Activities of Betulinic Acid: A Review |
| - | Review, | Nor, | NA |
| 5926- | CAR, | An Updated Review of Research into Carvacrol and Its Biological Activities |
| - | Review, | Nor, | NA | - | Review, | AD, | NA | - | Review, | Asthma, | NA |
| 6702- | DFC, | Diclofenac |
| - | Review, | Nor, | NA |
| 1085- | DHA, | EPA, | DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells |
| - | in-vitro, | Nor, | HUVECs |
| 6819- | EMD, | Recent advances in the therapeutic potential of emodin for human health |
| - | Review, | Nor, | NA |
| 6897- | FIS, | Fisetin: A Dietary Antioxidant for Health Promotion |
| - | Review, | Nor, | NA |
| 6995- | Form, | Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia |
| - | Review, | Nor, | BV2 |
| 7028- | GA, | Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases |
| - | Review, | Nor, | NA |
| - | in-vitro, | Nor, | RAW264.7 |
| 7108- | GEN, | Genistein: A Review on its Anti-Inflammatory Properties |
| - | Review, | Nor, | NA |
| 7142- | GI, | Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer |
| - | Trial, | Nor, | NA |
| 7151- | GI, | A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | Nor, | RAW264.7 |
| 7111- | GSL, | In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens |
| - | NA, | Nor, | NA |
| 7884- | isoO, | Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome |
| - | in-vitro, | Nor, | RAW264.7 |
| 8080- | KAE, | Hepatoprotective Effect of Kaempferol—A Review |
| - | Review, | Nor, | NA |
| 8221- | LCA, | Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects |
| - | in-vitro, | Nor, | NA |
| 8229- | LCA, | Licochalcone A: a review of its pharmacology activities and molecular mechanisms |
| - | Review, | Nor, | NA |
| 1084- | LT, | CHr, | Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells |
| - | in-vitro, | Nor, | RAW264.7 |
| 4528- | MAG, | Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update |
| - | Review, | Nor, | NA |
| 3474- | MF, | Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration |
| - | in-vitro, | Nor, | NA |
| 1680- | PBG, | Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, a Propolis Derivative |
| - | in-vitro, | Nor, | HS68 |
| 3099- | RES, | Resveratrol and cognitive decline: a clinician perspective |
| - | Review, | Nor, | NA | - | NA, | AD, | NA |
| 6437- | T4O, | Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes |
| - | in-vitro, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:49 Cells:% prod#:% Target#:248 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid