IL18 Cancer Research Results

IL18, Interleukin 18: Click to Expand ⟱
Source:
Type:
High levels of IL-18 production may play a major role in the growth and metastasis of renal cancer. Higher expression of IL-18 is detected in various cancer cells.

IL-18 is often expressed in various cancers, including melanoma, colorectal cancer, breast cancer, and gastric cancer. Its expression can vary depending on the tumor type and the immune context. Elevated levels of IL-18 are frequently associated with the presence of tumor-infiltrating immune cells and can be produced by both immune and tumor cells.

High levels of IL-18 expression are often associated with a favorable prognosis in various cancers. Elevated IL-18 levels in the tumor microenvironment can correlate with increased immune cell infiltration and better overall survival.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
3225- EGCG,    Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway
- in-vitro, Nor, NA - in-vivo, Nor, NA
*RenoP↑, *NLRP3↓, *TXNIP↓, *ASC↓, *Casp1↓, *IL1β↓, *ROS↓, *TNF-α↓, *IL6↓, *IL18↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
3185- SFN,    Sulforaphane decreases oxidative stress and inhibits NLRP3 inflammasome activation in a mouse model of ulcerative colitis
- in-vivo, Nor, RAW264.7
*IL18↓, *IL1β↓, *NLRP3↓, *Inflam↓,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp8↑, 1,   Fas↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   TNF-α↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 2,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 4,   SOD↑, 1,   SOD1↑, 1,   UCPs↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   PPARα↑, 1,   SIRT1↑, 2,   SREBP1↓, 1,  

Cell Death ⓘ

Apoptosis↓, 2,   Casp1↓, 3,   iNOS↓, 1,   Pyro?, 1,   TRPV1↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,  

Migration ⓘ

MMP9↑, 1,   TXNIP↓, 2,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   ATF4↓, 1,   eNOS↑, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

ASC?, 1,   ASC↓, 1,   IFN-γ↓, 1,   IL18↓, 5,   IL1β↓, 5,   IL2↓, 1,   IL6↓, 2,   Inflam↓, 3,   NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

hepatoP↑, 1,   OS↑, 1,   RenoP↑, 2,  
Total Targets: 49

Scientific Paper Hit Count for: IL18, Interleukin 18
1 Capsaicin
1 EGCG (Epigallocatechin Gallate)
1 Luteolin
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:369  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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