Cyc Cancer Research Results

Cyc, Cyclin: Click to Expand ⟱
Source:
Type:
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27↑, P53↑, VEGF↓, MAPK↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   NRF2↑, 1,   ROS↑, 1,   SOD↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp8↑, 1,   MAPK↓, 1,   p27↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   Cyc↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   Shh↓, 1,   Smo↓, 1,   Sufu↑, 1,   TumCG↓, 1,  

Migration ⓘ

GLI2↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 1,   selectivity↑, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Cyc, Cyclin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:374  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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