IGF-1 Cancer Research Results

IGF-1, insulin-like growth factor-1: Click to Expand ⟱
Source:
Type:
Higher blood levels of IGF-1, a growth factor, are linked to increased risk of several types of cancer, including thyroid, melanoma and myeloma. IGF-1 is what some call "a growth-promoter" because it has been shown to promote the growth of cancer cells.
The IGF-1 signaling pathway promotes cancer progression; its downregulation is associated with lowered risk.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2265- dietMet,    Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
- in-vivo, Nor, NA
*SCD1↓, *Weight↓, *Insulin↓, *IGF-1↓, *adiP↑, *eff↓,
5232- Ex,    Resistance training effect on serum insulin-like growth factor 1 in the serum: a meta-analysis
- Review, Nor, NA
*IGF-1↑, *IGF-1↓,
5234- Ex,    Intense Walking Exercise Affects Serum IGF-1 and IGFBP3
- Trial, Nor, NA
*IGF-1↓, *IGFBP3↓,
5235- Ex,    Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
- Trial, Nor, NA
Insulin↓, IGF-1↓, IGFBP1↑, eff↑,
3255- PBG,    Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2
- in-vivo, Nor, NA
*IGF-1↓, *MMP2↑, *ROS↓, *Inflam↓, *IL10↓, *NRF2∅,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSTs↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 2,   IGFBP1↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx?, 1,   Catalase↑, 1,   GSH↑, 2,   HO-1↑, 1,   MDA↓, 2,   NQO1↑, 1,   NRF2↑, 1,   NRF2∅, 1,   ROS↓, 1,   mt-ROS↓, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 2,   mtDam↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   AMPK↑, 1,   CRM↑, 1,   FGF21↑, 1,   glucose↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   Glycolysis↝, 1,   H2S↑, 1,   HK2↑, 2,   LDHA↑, 1,   PFK↑, 1,   PKM2↑, 2,   PPARα↑, 1,   SCD1↓, 1,   SIRT2↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 7,   IGF-1↑, 1,   IGFBP3↓, 1,   IGFR↓, 1,   mTOR↓, 1,  

Migration ⓘ

MMP2↑, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Barriers & Transport ⓘ

GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   motorD↑, 1,   neuroP↑, 1,   OS↑, 1,   Weight↓, 1,  
Total Targets: 50

Scientific Paper Hit Count for: IGF-1, insulin-like growth factor-1
3 Exercise
2 diet Methionine-Restricted Diet
2 Resveratrol
1 Betulinic acid
1 Propolis -bee glue
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:415  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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