ICAM-1 Cancer Research Results

ICAM-1, Intercellular Adhesion Molecule 1: Click to Expand ⟱
Source:
Type:
ICAM-1 also known as CD54 is a protein that in humans is encoded by the ICAM1 gene. ICAM-1 is an important regulator of cell–cell interactions and recent studies have shown that it promotes malignancy in several carcinomas.
Intercellular Adhesion Molecule 1 (ICAM-1) is a cell surface glycoprotein that plays a critical role in the immune response by facilitating the adhesion of leukocytes to endothelial cells. It is part of the immunoglobulin superfamily and is involved in various cellular processes, including inflammation, immune response, and tumor progression.
Expression in Cancers: ICAM-1 is often overexpressed in various types of cancers, including breast, lung, colorectal, and melanoma. Its expression can be induced by pro-inflammatory cytokines, growth factors, and other stimuli present in the tumor microenvironment.
Prognostic Implications: The expression levels of ICAM-1 have been associated with cancer prognosis. In some studies, high levels of ICAM-1 expression correlate with poor prognosis, increased tumor aggressiveness, and a higher likelihood of metastasis.

ICAM-1 is an adhesion molecule that is often overexpressed in various cancers and is associated with poor prognosis and increased metastatic potential.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2669- AL,  Rad,    Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway
- in-vitro, Nor, HUVECs
*ICAM-1↓, *AP-1↓, *p‑cJun↓, *radioP↑, JNK↓,
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1↓, *NF-kB↓, IKKα↓,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
2999- PL,    Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation
- in-vivo, Nor, HUVECs
*Inflam↓, *angioG↓, *Hif1a↓, *VEGF↓, *ICAM-1↓, *VCAM-1↓, *neuroP↑,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,
3189- SFN,    Sulforaphane Inhibits TNF-α-Induced Adhesion Molecule Expression Through the Rho A/ROCK/NF-κB Signaling Pathway
- in-vitro, Nor, ECV304
*ICAM-1↓, *IL1β↓, *IL6↓, *IL8↓, *p‑IKKα↓, *Rho↓, *ROCK1↓, *ERK↓, *Inflam↓,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

JNK↓, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   Inflam↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx↑, 1,   GSR↑, 1,   GSSG↓, 1,   HO-1↑, 3,   MDA↓, 1,   NOX4↓, 2,   NRF2↑, 1,   ROS↓, 3,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   LDH↓, 1,   PGC1A↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Migration ⓘ

AP-1↓, 1,   E-sel↓, 4,   Rho↓, 2,   ROCK1↓, 2,   TumCP↓, 1,   VCAM-1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,   NO↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 9,   IFN-γ↓, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 5,   MCP1↓, 2,   NF-kB↓, 5,   p‑NF-kB↓, 1,   p65↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TLR4∅, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 2,  

Clinical Biomarkers ⓘ

IL6↓, 3,   LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   radioP↑, 2,  
Total Targets: 60

Scientific Paper Hit Count for: ICAM-1, Intercellular Adhesion Molecule 1
2 Radiotherapy/Radiation
2 Alpha-Lipoic-Acid
1 Allicin (mainly Garlic)
1 Betulinic acid
1 Ginger/6-Shogaol/Gingerol
1 Piperlongumine
1 Rosmarinic acid
1 Sulforaphane (mainly Broccoli)
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:419  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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