VCAM-1 Cancer Research Results

VCAM-1, Vascular cell adhesion protein 1: Click to Expand ⟱
Source:
Type:
A protein that in humans is encoded by the VCAM1 gene.
VCAM-1 is a cell surface glycoprotein primarily expressed by activated endothelial cells.
It mediates adhesion of leukocytes and plays a key role in inflammation and immune cell trafficking.
In the tumor microenvironment, VCAM-1 is often upregulated and is involved in the interactions between tumor cells, immune cells, and the vasculature.

VCAM-1 is predominantly protumorigenic in cancer contexts. Its upregulation in tumor tissues and vasculature contributes to enhanced tumor cell adhesion, migration, and metastasis, and correlates with poor clinical outcomes.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1↓, *NF-kB↓, IKKα↓,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
2999- PL,    Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation
- in-vivo, Nor, HUVECs
*Inflam↓, *angioG↓, *Hif1a↓, *VEGF↓, *ICAM-1↓, *VCAM-1↓, *neuroP↑,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   Inflam↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx↑, 1,   GSR↑, 1,   GSSG↓, 1,   HO-1↑, 3,   MDA↓, 1,   NOX4↓, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   LDH↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,  

Migration ⓘ

E-sel↓, 4,   TumCP↓, 1,   VCAM-1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,   NO↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 1,   IKKα↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 3,   MCP1↓, 1,   NF-kB↓, 5,   p65↓, 1,   PGE2↓, 1,   TLR4∅, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,   LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,  
Total Targets: 50

Scientific Paper Hit Count for: VCAM-1, Vascular cell adhesion protein 1
2 Alpha-Lipoic-Acid
1 Betulinic acid
1 Ginger/6-Shogaol/Gingerol
1 Piperlongumine
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:420  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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