ABC Cancer Research Results

ABC, ABC transporter: Click to Expand ⟱
Source:
Type:
ABC (ATP-binding cassette) transporters are a family of proteins that play a crucial role in the transport of various molecules across cell membranes.
ABC transporters have been implicated in the development of multidrug resistance, which is a major obstacle in cancer treatment.
Overexpression of certain ABC transporters, such as P-glycoprotein (P-gp), has been observed in various types of cancer, including breast, lung, and colon cancer.
Examples of ABC transporters implicated in cancer include:
- P-glycoprotein (P-gp, ABCB1)
- Multidrug resistance-associated protein 1 (MRP1, ABCC1)
- Breast cancer resistance protein (BCRP, ABCG2)
Prognostic Implications
-Drug Resistance: High expression of ABC transporters is often linked to resistance against chemotherapy, leading to treatment failure and poor patient outcomes.
-Survival Rates: Patients with tumors expressing high levels of certain ABC transporters may have lower overall survival rates.
Target for Therapy: Inhibitors of ABC transporters are being explored as potential adjuncts to improve the efficacy of chemotherapy.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5649- BNL,    Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability
- Review, Nor, NA
*BBB↑, *other↑, *P-gp↓, *toxicity⇅, *BioAv⇅, *Dose↑, *ABC↓, *MRP1↓, *5HT↑, *GABA↑, *eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   GABA↑, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv⇅, 1,   Dose↑, 1,   eff↑, 1,   MRP1↓, 1,  

Functional Outcomes ⓘ

toxicity⇅, 1,  
Total Targets: 11

Scientific Paper Hit Count for: ABC, ABC transporter
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:621  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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