SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱
Source:
Type:
SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
2339- QC,    Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *Sepsis↓, *PKM2↓, *SIRT1↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NADH↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   MPT↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp↑, 1,   Cyt‑c↑, 1,   p38↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 1,  

Migration ⓘ

TRIB3↑, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  

Clinical Biomarkers ⓘ

TRIB3↑, 1,  

Functional Outcomes ⓘ

Obesity↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,   SIRT1↓, 2,  

Cell Death ⓘ

iNOS↓, 1,   TRPV1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Migration ⓘ

Ca+2↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   NHE3↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   neuroP↑, 1,   RenoP↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 30

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein
1 Capsaicin
1 Quercetin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:634  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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