p70S6 Cancer Research Results

p70S6, phospho-S6: Click to Expand ⟱
Source:
Type:
p70S6, also known as phospho-S6, is the phosphorylated form of the S6 protein, which is a component of the 40S ribosomal subunit. The S6 protein is a key regulator of protein synthesis, and its phosphorylation by p70S6K is a critical event in the regulation of translation.
Overexpressed in: breast, prostate, lung CRC pancreatic, ovarian, Melanoma, HCC, RCC, throid, Esophageal, stomach.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
948- F,    Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia
- vitro+vivo, Bladder, T24/HTB-9 - in-vitro, Nor, HUVECs
p‑PI3k/Akt/mTOR↓, p‑p70S6↓, p‑4E-BP1↓, angioG↓, Hif1a↓, VEGF↑, TumCG↓, TumVol↓, TumW↓, Iron∅, ROS↓,
2892- HNK,    Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, H385 - in-vitro, Nor, BEAS-2B
TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Iron∅, 1,   ROS↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis ⓘ

p‑PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   p‑p70S6↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑4E-BP1↓, 1,   p‑mTOR↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   VEGF↑, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,  

Kinase & Signal Transduction ⓘ

p‑p70S6↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: p70S6, phospho-S6
1 Fucoidan
1 Honokiol
1 Huperzine A/Huperzia serrata
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:733  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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