IGFR Cancer Research Results

IGFR, Insulin-like Growth Factor Receptor: Click to Expand ⟱

Source:

Type: Oncogene

IGFR (Insulin-like Growth Factor Receptor) is a protein that plays a crucial role in cell growth and division. It is a receptor tyrosine kinase that is activated by its ligands, IGF-1 (Insulin-like Growth Factor 1) and IGF-2.
IGFR is typically overexpressed and associated with poorer prognosis.
IGF-1R is often overexpressed in several types of cancers, including breast cancer, prostate cancer, colorectal cancer, lung cancer, and sarcomas. Its expression can vary significantly depending on the tumor type and stage.
High levels of IGF-1R expression are frequently associated with aggressive tumor behavior and poor prognosis.
IGF-1R is considered an oncogene due to its role in promoting cell proliferation, survival, and metastasis. Activation of IGF-1R leads to the activation of several downstream signaling pathways, including the PI3K/Akt and MAPK pathways, which are critical for cell growth and survival.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

2333-

RES,

Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells

in-vitro,

Nor,

SD rats received a high-fat diet and letrozole for 30 days to
establish the PCOS model

*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,

Core Metabolism/Glycolysis ⓘ

glucose↓, 1, Glycolysis↝, 1, HK2↑, 1, LDHA↑, 1, PKM2↑, 1, SIRT2↑, 1,

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1, IGFR↓, 1,
Total Targets: 9

Scientific Paper Hit Count for: IGFR, Insulin-like Growth Factor Receptor

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells