TRPM7 Cancer Research Results

TRPM7, transient receptor potential melastatin 7: Click to Expand ⟱
Source:
Type:
TRPM7 (transient receptor potential melastatin 7) is a member of the TRP family of ion channels, which play a crucial role in various cellular processes, including cell growth, differentiation, and survival.
High TRPM7 expression is associated with reduced overall survival in various types of cancer, including breast, lung, colon, prostate, ovarian, pancreatic, and glioblastoma.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5908- CAR,    Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI
- in-vivo, Nor, NA
*TRPM7↓, *BBB↑, *motorD↑, *cognitive↑, *Dose↝, MMPs↓,
5912- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, p‑Cofilin↑, RAS↓, MEK↓, MAPK↓, PI3K↓, Akt↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MEK↓, 2,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 1,   MAPK↓, 2,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 2,   RAS↓, 1,   TRPM7↓, 2,  

Migration ⓘ

p‑Cofilin↑, 2,   F-actin↓, 1,   MMP2↓, 2,   MMPs↓, 1,   TumCI↓, 2,   TumCMig↓, 2,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

TRPM7↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   motorD↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: TRPM7, transient receptor potential melastatin 7
3 Carvacrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:883  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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