ERα/ESR1 Cancer Research Results

ERα/ESR1, Estrogen Receptor alpha: Click to Expand ⟱
Source:
Type:
ERα (Estrogen Receptor alpha) is a subtype of estrogen receptor that plays a crucial role in the development and progression of various types of cancer.
Cancers with high ERα expression (>50%):BC(80%),EC(80%),OC,Uterine sarcoma
Cancers with moderate ERα expression (20-50%):CRC, PCa, Vulvar
Cancers with low ERα expression (<20%):Lung, PC, GC

ESR1 is used as a clinical biomarker for Endocrine Therapy
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
977- SK,    A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, HMEC
TumCG↓, ERα/ESR1↓, selectivity↑, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

ERα/ESR1↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ERα/ESR1, Estrogen Receptor alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:937  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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