TCF-4 Cancer Research Results

TCF-4, Transcription Factor 4: Click to Expand ⟱

Source:

Type:

TCF4 gene (Transcription Factor 4) is a transcription factor that plays a crucial role in the Wnt/β-catenin signaling pathway, which is involved in cell proliferation, differentiation, and survival.
TCF4 gene has been found to be:
     Amplified in 15% of breast cancer cases
     Mutated in 10% of lung cancer cases
     Deleted in 20% of prostate cancer cases
     Methylated in 30% of colorectal cancer cases

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

1012-

EGCG,

Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations

in-vitro,

Nor,

HEK293

10-12uM EGCG

*H2O2↑, *β-catenin/ZEB1↓, *TCF-4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

H2O2↑, 1,

Proliferation, Differentiation & Cell State ⓘ

TCF-4↓, 1,

Migration ⓘ

β-catenin/ZEB1↓, 1,
Total Targets: 3

Scientific Paper Hit Count for: TCF-4, Transcription Factor 4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells