EP2 Cancer Research Results

EP2, Prostaglandin E2 receptor 2: Click to Expand ⟱
Source:
Type:
Also known as PTGER2
EP2 (Prostaglandin E2 receptor 2) is a receptor that plays a role in various cellular processes, including inflammation and cell growth. In cancer, EP2 has been implicated in tumor development and progression.
Tumorigenic potential:
-promote tumorigenesis by enhancing cell proliferation and survival
-Increasing angiogenesis (formation of new blood vessels)
-Suppressing apoptosis (programmed cell death)
-Promoting invasion and metastasis

Expression levels in cancer:
Overexpressed in:Colorectal, Breast, Lung, Prostate, and Ovarian cancer (with generally poor prognosis)
Underexpressed in:Some types of gastric cancer (correlated with improved overall survival)
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: EP2, Prostaglandin E2 receptor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:969  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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