COX1 Cancer Research Results

COX1, COX-1: Click to Expand ⟱
Source:
Type:
COX‑1 is traditionally considered a constitutively expressed enzyme involved in “housekeeping” functions, while COX‑2 is more frequently studied in relation to cancer.
• The prognostic impact of COX‑1 may vary based on cancer subtype, stage, and interplay with other inflammatory mediators (e.g., COX‑2).
• Many studies assess combined cyclooxygenase profiles (COX‑1/COX‑2) rather than COX‑1 alone.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5413- ASA,    Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin
- Trial, Nor, NA
*cardioP↑, *other↝, *COX1↓, *TXA2↓,
5400- ASA,    Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention
- Review, Nor, NA
Risk↓, *Inflam↓, *COX1↓, *AntiAg↑, *Half-Life↓, *BioAv↑,
5401- ASA,    Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15R-prostaglandins that inhibit platelet aggregation
- Review, Nor, NA
*AntiAg↑, *COX1↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,
2466- CUR,    Regulatory Effects of Curcumin on Platelets: An Update and Future Directions
- Review, Nor, NA
*AntiAg↑, *antiOx↑, *Inflam↓, *12LOX↑, COX1↓, COX2↓, MMP9↓, NF-kB↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   MMP2↓, 1,   MMP9↓, 2,   TumCI↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 2,   COX2↓, 2,   NF-kB↓, 2,  

Functional Outcomes ⓘ

Risk↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   HO-1↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Migration ⓘ

AntiAg↑, 3,  

Angiogenesis & Vasculature ⓘ

TXA2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 3,   Inflam↓, 2,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Half-Life↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: COX1, COX-1
3 Aspirin -acetylsalicylic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:998  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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