BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
Source:
Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3538- 5-HTP,    Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
- in-vivo, Nor, NA
*GutMicro↑, *BBB↑, *5HT↑, *Weight↓,
4368- AgNPs,    Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro
- NA, Nor, NA
*BBB↑,
5649- BNL,    Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability
- Review, Nor, NA
*BBB↑, *other↑, *P-gp↓, *toxicity⇅, *BioAv⇅, *Dose↑, *ABC↓, *MRP1↓, *5HT↑, *GABA↑, *eff↑,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp↓, eff↑, other↝,
5665- BNL,    Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies
- in-vivo, Nor, NA
*BBB↑, eff↑,
5667- BNL,    Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
- in-vivo, Nor, NA
*BioEnh↑, *eff↑, *BBB↑,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5908- CAR,    Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI
- in-vivo, Nor, NA
*TRPM7↓, *BBB↑, *motorD↑, *cognitive↑, *Dose↝, MMPs↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2873- HNK,    Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- in-vitro, Nor, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,

Showing Research Papers: 1 to 13 of 13

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Migration ⓘ

MMPs↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose↓, 1,   eff↑, 2,  

Functional Outcomes ⓘ

cognitive↑, 1,   toxicity↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   Ferroptosis↓, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 1,   H2O2↓, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 1,   MPO↓, 1,   NRF2↑, 3,   ROS↓, 5,   SOD↑, 3,   TAC↑, 1,   Trx1↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   ACSL4↓, 1,   CYP3A4↓, 1,   NADPH↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Ferroptosis↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TRPM7↓, 1,  

Migration ⓘ

TGF-β1↑, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   CLDN5↑, 1,   EPR↑, 1,   NO↓, 2,   NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 12,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL10↑, 1,   IL1β↓, 1,   IL6↓, 2,   IL6↑, 1,   Inflam↓, 4,   NF-kB↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

5HT↑, 2,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 1,   BioAv↑, 1,   BioAv⇅, 1,   BioAv↝, 1,   BioEnh↑, 2,   Dose↑, 1,   Dose↝, 1,   eff↑, 7,   Half-Life↑, 1,   Half-Life↝, 1,   MRP1↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 2,   IL6↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 8,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 1,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 83

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
5 borneol
1 5-Hydroxytryptophan
1 Silver-NanoParticles
1 Carvacrol
1 Fisetin
1 Honokiol
1 Lycopene
1 Quercetin
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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