CRM Cancer Research Results

CRM, Calorie restriction mimetics (CRMs): Click to Expand ⟱
Source:
Type:
Calorie restriction mimetics (CRMs) are compounds that appear to mimic some of the biochemical effects of caloric restriction without the need to actually reduce caloric intake.

-Resveratrol:Known for activating sirtuins (e.g., SIRT1)
-Curcumin
-Quercetin
-EGCG
-Spermidine
-Fisetin
-Berberine
-Pterostilbene
-Hydroxytyrosol
-Sulforaphane
-Cinnamaldehyde
-Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)
-Alpha-Ketoglutarate (AKG)
-Rapamycin (Sirolimus
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5793- ASA,    Aspirin Recapitulates Features of Caloric Restriction
- in-vitro, Nor, NA
*CRM↑, *HATs↓, *NF-kB↓, *EP300↓,
1535- Ba,    Baicalein May Act as a Caloric Restriction Mimetic Candidate to Improve the Antioxidant Profile in a Natural Rodent Model of Aging
- in-vivo, Nor, NA
*antiOx↑, *ROS∅, *CRM↑,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
5787- NAD,    Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
- in-vitro, Nor, NA
*CRM↑, *OS↑,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
5794- Sper,    Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- in-vitro, Nor, U2OS
*EP300↓, *mTORC1↓, *CRM↑, *HATs↓, *p62↓, *AntiAge↑, AntiCan↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   CRM↑, 1,   lipoGen↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   Risk↓, 1,   toxicity∅, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS∅, 1,   SOD2↑, 1,   TAC↑, 1,   TrxR1↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↓, 2,   OCR↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 3,   CRM↑, 7,   LDL↓, 1,   SIRT1↑, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 2,  

Protein Folding & ER Stress ⓘ

NQO2↑, 1,  

Autophagy & Lysosomes ⓘ

p62↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 2,   IGF-1↓, 1,   mTORC1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   BP↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 3,   AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 2,   motorD↑, 1,   OS↑, 1,   Strength↑, 1,   toxicity⇅, 1,  
Total Targets: 35

Scientific Paper Hit Count for: CRM, Calorie restriction mimetics (CRMs)
2 Resveratrol
1 Aspirin -acetylsalicylic acid
1 Baicalein
1 HydroxyCitric Acid
1 Metformin
1 nicotinamide adenine dinucleotide
1 Spermidine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1128  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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