IGFBP1 Cancer Research Results

IGFBP1, Insulin-like Growth Factor Binding Protein 1: Click to Expand ⟱

Source:

Type:

IGFBP1 is one of several binding proteins that modulate IGF (insulin-like growth factor) availability and signaling, which can affect cell proliferation, apoptosis, and cellular metabolism.

– In some cohorts, higher circulating or tissue levels of IGFBP1 have been associated with a less aggressive disease phenotype and better overall survival.

– Conversely, in other studies, low IGFBP1 levels have been linked with a more advanced disease state, suggesting that IGFBP1 may serve as an indicator of preserved liver function or a less aggressive tumor biology.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

5235-

Ex,

Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

Trial,

Nor,

 Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks.

Insulin↓, IGF-1↓, IGFBP1↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1, IGFBP1↑, 1,

Drug Metabolism & Resistance ⓘ

eff↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: IGFBP1, Insulin-like Growth Factor Binding Protein 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells